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Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 8, doi: 10.1007/s11783-022-1527-6
• The promoting effects for VFA generation follow the order of APG>SDBS>HTAB.
Keywords: Waste activated sludge (WAS) Volatile fatty acids (VFA) Surfactant types Functional microorganisms Metabolicactivity upregulation
Clemens Drenowatz, Joseph J. Carlson, Karin A. Pfeiffer, Joey C. Eisenmann
Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 428-435 doi: 10.1007/s11684-012-0232-4
Keywords: exercise sedentary behavior metabolic syndrome health behavior adolescents TV time healthy eating index
Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 106-112 doi: 10.1007/s11684-014-0307-5
Keywords: cervical cancer senescence Twist CBX3 lymph node metastasis
Metabolic hypertension: concept and practice
Zhiming Zhu, Peijian Wang, Shuangtao Ma
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 201-206 doi: 10.1007/s11684-013-0264-4
Keywords: hypertension cardiometabolic risk factors metabolic abnormalities
Jianping Ye
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 139-145 doi: 10.1007/s11684-015-0377-z
In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissue function. Although this view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulin sensitivity through induction of energy expenditure. In this review article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatory cytokines. IL-15 is secreted by multiple types of cells including macrophages, neutrophils and skeletal muscle cells. IL-15 expression is induced in immune cells by endotoxin and in muscle cells by physical exercise. Its transcription is induced by transcription factor NF-κB. IL-15 binds to its receptor that contains three different subunits (α, β and γ) to activate JAK/STAT, PI3K/Akt, IKK/NF-κB and JNK/AP1 pathways in cells. In the regulation of metabolism, IL-15 reduces weight gain without inhibiting food intake in rodents. IL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight loss and energy expenditure. In human, circulating IL-15 is negatively associated with body weight. In the immune system, IL-15 stimulates proliferation and differentiation of T cells, NK cells, monocytes and neutrophils. In the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is required. In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity and type 2 diabetes. The mechanism of IL-15 action remains to be fully uncovered in the regulation of energy expenditure.
Keywords: inflammation obesity cytokine energy expenditure insulin resistance
Frontiers of Medicine 2021, Volume 15, Issue 5, Pages 679-692 doi: 10.1007/s11684-021-0866-1
Keywords: metabolic reprogramming potential of electron transfer cell proliferation aerobic glycolysis cancer
Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology
Huating Li, Jing Zhang, Weiping Jia
Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 25-30 doi: 10.1007/s11684-013-0244-8
Keywords: FGF21 metabolism pharmacology physiology clinical relevance
Construction, characterization and application of a genome-wide promoter library in
Ting Yuan,Yakun Guo,Junkai Dong,Tianyi Li,Tong Zhou,Kaiwen Sun,Mei Zhang,Qingyu Wu,Zhen Xie,Yizhi Cai,Limin Cao,Junbiao Dai
Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1, Pages 107-116 doi: 10.1007/s11705-017-1621-7
Keywords: synthetic biology yeast promoter activity metabolic engineering xylose utilization
Metformin and metabolic diseases: a focus on hepatic aspects
Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 173-186 doi: 10.1007/s11684-015-0384-0
Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), serving as the main mechanism by which metformin improves hyperglycemia of T2D. Biochemically, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D. These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty liver disease. As supported by the results from both human and animal studies, metformin improves hepatic steatosis and suppresses liver inflammation. Mechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases.
Keywords: metformin diabetes hepatic steatosis inflammatory response insulin resistance
Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1433-3
• Short-term effect of the pyridine exposure on the SAD process was investigated.
Keywords: Anammox Inhibition Metabolic pathway Microbial community Pyridine SAD
Water-dispersible nano-pollutions reshape microbial metabolism in type-specific manners: A metabolic
Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 9, doi: 10.1007/s11783-022-1548-1
• Water-dispersible nano-pollutions exhibit type-specific toxic effects on E. coli.
Keywords: Nano-toxicity Nano-plastics Quantum dots Microbial metabolite Metabolic dysregulation
Xiaokun Li
Frontiers of Medicine 2019, Volume 13, Issue 5, Pages 511-530 doi: 10.1007/s11684-019-0711-y
Keywords: FGF19 FGF21 FGF23 FGFR metabolism endocrine Klotho
Regulation of T cell immunity by cellular metabolism
Zhilin Hu, Qiang Zou, Bing Su
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 463-472 doi: 10.1007/s11684-018-0668-2
Keywords: T cell immunity metabolic pathways nutrient uptake metabolic checkpoints
Zinc homeostasis in the metabolic syndrome and diabetes
Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai
Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 31-52 doi: 10.1007/s11684-013-0251-9
Keywords: zinc zinc transporters metallothionein diabetes diabetic complications insulin resistance antioxidant
Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1637-9
● Converting xylose to caproate under a low temperature of 20 °C by MCF was verified.
Keywords: Xylose fermentation Caproate Low temperature Bifidobacterium FAB pathway RBO pathway
Title Author Date Type Operation
New insights into different surfactants’ impacts on sludge fermentation: Focusing on the particular metabolic
Journal Article
Joint association of physical activity/screen time and diet on CVD risk factors in 10-year-old children
Clemens Drenowatz, Joseph J. Carlson, Karin A. Pfeiffer, Joey C. Eisenmann
Journal Article
Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical
Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang
Journal Article
Metabolic hypertension: concept and practice
Zhiming Zhu, Peijian Wang, Shuangtao Ma
Journal Article
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes
Jianping Ye
Journal Article
electron transfer and its application in dictating routes of biochemical processes associated with metabolic
Journal Article
Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology
Huating Li, Jing Zhang, Weiping Jia
Journal Article
Construction, characterization and application of a genome-wide promoter library in
Ting Yuan,Yakun Guo,Junkai Dong,Tianyi Li,Tong Zhou,Kaiwen Sun,Mei Zhang,Qingyu Wu,Zhen Xie,Yizhi Cai,Limin Cao,Junbiao Dai
Journal Article
Metformin and metabolic diseases: a focus on hepatic aspects
Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu
Journal Article
denitrification system with short-term pyridine exposure: Process capability, inhibition kinetics and metabolic
Journal Article
Water-dispersible nano-pollutions reshape microbial metabolism in type-specific manners: A metabolic
Journal Article
Zinc homeostasis in the metabolic syndrome and diabetes
Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai
Journal Article